2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

Base Information

Chemical Name:2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol
CAS No.:1307813-33-7
Molecular Formula:C₂₁H₁₃F₃N₂O₂S
Molecular Weight:414.408
Hs Code.:

Synonyms:2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

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Chemical Property of 2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

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Technology Process of 2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

There total 1 articles about 2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1307813-31-5
5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

: 1307813-33-7
2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/acs.jmedchem.6b01099

Reference yield: 89.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1307813-33-7
2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

: 1307813-34-8
2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl trifluoromethanesulfonate

Guidance literature:: In pyridine; at 0 ℃; for 2.5h;
DOI:10.1021/acs.jmedchem.6b01099

Reference yield:

: 1307813-33-7
2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

: 1307810-21-4
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 2.5 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere; Microwave irradiation

3.1: osmium(VIII) oxide; sodium periodate / butan-1-ol; water; tetrahydrofuran / 1.5 h / 20 °C

4.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 80 °C

4.2: 1 h / 20 °C

With pyridine; methanol; sodium periodate; osmium(VIII) oxide; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; butan-1-ol;