3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole

Base Information

• Chemical Name: 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole
• CAS No.: 1307813-35-9
• Molecular Formula: C₂₃H₁₅F₃N₂OS
• Molecular Weight: 424.446
• Mol file: 1307813-35-9.mol

Synonyms:3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole

Chemical Property of 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole

There total 3 articles about 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl trifluoromethanesulfonate (1307813-34-8) + tri-n-butyl(vinyl)tin (7486-35-3) → 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole (1307813-35-9)

Guidance literature:

With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 6h; Inert atmosphere; Microwave irradiation;

Reference yield:

5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole (1307813-31-5) → 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole (1307813-35-9)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 4.5 h / 20 °C

2: pyridine / 2.5 h / 0 - 20 °C

3: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere; Microwave irradiation

With pyridine; boron tribromide; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;

Reference yield:

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol (1307813-33-7) → 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole (1307813-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2.5 h / 0 - 20 °C

2: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere; Microwave irradiation

With pyridine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;

upstream raw materials:

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl trifluoromethanesulfonate

tri-n-butyl(vinyl)tin

5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

Downstream raw materials:

1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt

2-(3-phenyl-4-(trifluoromethyl )isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazole-7-carbaldehyde

1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

C₂₃H₁₇F₃N₂O₃S