5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

Base Information

• Chemical Name: 5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole
• CAS No.: 1307813-31-5
• Molecular Formula: C₂₂H₁₅F₃N₂O₂S
• Molecular Weight: 428.435
• Mol file: 1307813-31-5.mol

Synonyms:5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

Chemical Property of 5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

There total 1 articles about 5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide (1307812-93-6) → 5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole (1307813-31-5)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; at 140 ℃; for 0.8h; Microwave irradiation;

Reference yield: 100.0%

5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole (1307813-31-5) → 2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol (1307813-33-7)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/acs.jmedchem.6b01099

Reference yield:

5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole (1307813-31-5) → 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt (1307810-21-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 4.5 h / 20 °C

2.1: pyridine / 2.5 h / 0 - 20 °C

3.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere; Microwave irradiation

4.1: osmium(VIII) oxide; sodium periodate / butan-1-ol; water; tetrahydrofuran / 1.5 h / 20 °C

5.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 80 °C

5.2: 1 h / 20 °C

With pyridine; methanol; sodium periodate; osmium(VIII) oxide; boron tribromide; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; butan-1-ol;

upstream raw materials:

N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

Downstream raw materials:

1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl trifluoromethanesulfonate

3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole