ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate

Base Information

• Chemical Name: ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate
• CAS No.: 126535-86-2
• Molecular Formula: C₁₃H₁₄F₃NO₅
• Molecular Weight: 321.253
• Mol file: 126535-86-2.mol

Synonyms:ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate

Chemical Property of ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate

There total 10 articles about ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

O-benzyl carbamate (621-84-1) + ethyl-3,3,3-trifluoropyruvate (13081-18-0) → ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate (126535-86-2)

Guidance literature:

In dichloromethane;

Reference yield: 37.0%

ethyl (Z)-2-(((benzyloxy)carbonyl)imino)-3,3,3-trifluoropropanoate + 1,3-Dimethoxybenzene (151-10-0) → ethyl 2-(((benzyloxy)carbonyl)amino)-2-(2,4-dimethoxyphenyl)-3,3,3-trifluoropropanoate + ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate (126535-86-2)

Guidance literature:

With trifluorormethanesulfonic acid; In chloroform-d1;

DOI:10.1021/acs.orglett.0c01895

Reference yield:

ethyl 2-(((benzyloxy)carbonyl)amino)-2-chloro-3,3,3-trifluoropropanoate → ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate (126535-86-2)

Guidance literature:

With silver carbonate; In chloroform-d1; at 20 ℃; for 24h; Molecular sieve; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01895

upstream raw materials:

O-benzyl carbamate

ethyl-3,3,3-trifluoropyruvate

ethyl 2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate

acetic acid

Downstream raw materials:

(N-Benzoxycarbonyl)-2-cyano-3,3,3-trifluoralaninethylester

2-Benzyl-2-[(R)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3,3,3-trifluoro-propionic acid ethyl ester

2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester

ethyl 2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate