2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester

Base Information

• Chemical Name: 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester
• CAS No.: 881853-81-2
• Molecular Formula: C₂₅H₂₅F₃N₂O₅
• Molecular Weight: 490.479
• Mol file: 881853-81-2.mol

Synonyms:

Chemical Property of 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester

There total 5 articles about 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-3,3,3-trifluoropyruvate (13081-18-0) → 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester (881853-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: (CF₃CO)2O; pyridine

2: CH₂Cl₂ / 3 h / 0 - 20 °C

With pyridine; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jm0511334

Reference yield:

ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate (126535-86-2) → 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester (881853-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (CF₃CO)2O; pyridine

2: CH₂Cl₂ / 3 h / 0 - 20 °C

With pyridine; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jm0511334

Reference yield:

(R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionic acid (3588-64-5,5123-55-7,32150-90-6,38229-08-2) → 2-[(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyric acid ethyl ester (881853-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-bromo-N,N,2-trimethyl-1,1-propenylamine / CH₂Cl₂ / 0.17 h

2: CH₂Cl₂ / 3 h / 0 - 20 °C

With 1-bromo-N,N,2-trimethyl-1-propen-1-amine; In dichloromethane;

DOI:10.1021/jm0511334

upstream raw materials:

(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide

ethyl-3,3,3-trifluoropyruvate

ethyl 2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate

ethyl 2-(((benzyloxy)carbonyl)amino)-3,3,3-trifluoro-2-hydroxypropanoate

Downstream raw materials:

[5-benzyloxycarbonylamino-2-(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoylamino]-3-phenyl-propionylamino}-3-methyl-2-trifluoromethyl-butyrylamino)-pentanoylamino]-acetic acid tert-butyl ester

((S)-5-Benzyloxycarbonylamino-2-{2-[(R)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyrylamino}-pentanoylamino)-acetic acid tert-butyl ester

((S)-2-{2-[(R)-2-((S)-2-Amino-pent-4-enoylamino)-3-phenyl-propionylamino]-3-methyl-2-trifluoromethyl-butyrylamino}-5-benzyloxycarbonylamino-pentanoylamino)-acetic acid

[3-((2S,8S,11R)-8-Allyl-11-benzyl-14-isopropyl-3,6,9,12,15-pentaoxo-14-trifluoromethyl-1,4,7,10,13-pentaaza-cyclopentadec-2-yl)-propyl]-carbamic acid benzyl ester