6-fluoro-3-methylisoquinoline

Base Information

• Chemical Name: 6-fluoro-3-methylisoquinoline
• CAS No.: 1221445-02-8
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.179
• Hs Code.: 2933499090
• Mol file: 1221445-02-8.mol

Synonyms:6-fluoro-3-methylisoquinoline

Chemical Property of 6-fluoro-3-methylisoquinoline

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

6-Fluoro-3-methylisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-fluoro-3-methylisoquinoline

There total 3 articles about 6-fluoro-3-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-bromo-4-fluorobenzaldehyde (59142-68-6) + prop-1-yne (74-99-7) → 6-fluoro-3-methylisoquinoline (1221445-02-8)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere; Cooling with ice; Sealed vessel;

Reference yield:

N-(4-fluorobenzyl)-1,1-dimethoxypropan-2-amine (1221445-01-7) → 6-fluoro-3-methylisoquinoline (1221445-02-8)

Guidance literature:

With chlorosulfonic acid; at -10 - 100 ℃;

Reference yield:

Pyruvic aldehyde dimethyl acetal (6342-56-9) + para-fluorobenzylamine (140-75-0) → 6-fluoro-3-methylisoquinoline (1221445-02-8)

Guidance literature:

Pyruvic aldehyde dimethyl acetal; para-fluorobenzylamine; With sodium tris(acetoxy)borohydride; at 20 ℃;

With chlorosulfonic acid; at 100 ℃;

DOI:10.1021/jm500916t

upstream raw materials:

N-(4-fluorobenzyl)-1,1-dimethoxypropan-2-amine

2-bromo-4-fluorobenzaldehyde

prop-1-yne

Pyruvic aldehyde dimethyl acetal

Downstream raw materials:

1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3R)-3-methyl-3-phenylcyclopentyl]urea

1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-(2-fluorophenyl)cyclopentyl]urea

1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1S,3S)-3-(2-fluorophenyl)cyclopentyl]urea

1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1S,3S)-3-phenylcyclopentyl]urea