Chemical Property of 1,1-Dimethoxyacetone
Chemical Property:
- Appearance/Colour:clear colorless to yellow liquid
- Vapor Pressure:4.96mmHg at 25°C
- Melting Point:-57 °C
- Refractive Index:n20/D 1.398(lit.)
- Boiling Point:145 °C at 760 mmHg
- Flash Point:37 °C
- PSA：35.53000
- Density:0.973 g/cm3
- LogP:0.19430
- Storage Temp.:Flammables area
- Water Solubility.:MISCIBLE
- XLogP3:-0.2
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:118.062994177
- Heavy Atom Count:8
- Complexity:75.7
- Purity/Quality:
-
99% *data from raw suppliers
Pyruvic Aldehyde Dimethyl Acetal *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
10-36/38
- Safety Statements:
26-36-16
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Classes -> Acetals
- Canonical SMILES:CC(=O)C(OC)OC
-
Uses
Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders. Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.
