6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

Base Information

Chemical Name:6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine
CAS No.:1288999-17-6
Molecular Formula:C₂₄H₂₅IN₆O₄
Molecular Weight:588.405
Hs Code.:

Synonyms:6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

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Chemical Property of 6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

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Technology Process of 6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

There total 3 articles about 6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1288998-86-6
6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-5'-O-benzoyl-2'-deoxyadenosine

: 107-13-1,25014-41-9
acrylonitrile

: 1288999-17-6
6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

Guidance literature:: With caesium carbonate; In tert-butyl alcohol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201001952

Reference yield:

: 166247-63-8,908130-61-0
7-deaza-2'-deoxy-7-iodoadenosine

: 1288999-17-6
6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 2 h / 50 °C

2: pyridine; dichloromethane / 1 h / -15 °C

3: caesium carbonate / tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With caesium carbonate; In pyridine; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/chem.201001952

Reference yield:

: 178420-85-4
6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-2'-deoxyadenosine

: 1288999-17-6
6-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3'-(2-cyanoethyl)-5'-O-benzoyl-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dichloromethane / 1 h / -15 °C

2: caesium carbonate / tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With caesium carbonate; In pyridine; dichloromethane; tert-butyl alcohol;
DOI:10.1002/chem.201001952