2,6-Dipropylpyridine

Base Information

• Chemical Name: 2,6-Dipropylpyridine
• CAS No.: 33354-88-0
• Molecular Formula: C11H17 N
• Molecular Weight: 163.26
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30462576
• Nikkaji Number: J28.094A
• Wikidata: Q82287128
• Mol file: 33354-88-0.mol

Synonyms:2,6-dipropylpyridine;33354-88-0;2,6-DIPROPYL PYRIDINE;SCHEMBL2522650;DTXSID30462576;AKOS006273590

Chemical Property of 2,6-Dipropylpyridine

Chemical Property:

• Boiling Point: 54-56 °C(Press: 4 Torr)
• PKA: 6.67±0.10(Predicted)
• PSA: 12.89000
• Density: 0.900±0.06 g/cm3(Predicted)
• LogP: 2.98660
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 163.136099547
• Heavy Atom Count: 12
• Complexity: 99.6

Purity/Quality:

99% ^*data from raw suppliers

2,6-DIPROPYL PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=NC(=CC=C1)CCC

Technology Process of 2,6-Dipropylpyridine

There total 8 articles about 2,6-Dipropylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,6-dichloropyridine (2402-78-0) + propyl bromide (106-94-5) → 2,6-di-n-propylpyridine (33354-88-0)

Guidance literature:

propyl bromide; With magnesium; In diethyl ether; at 20 ℃; for 1h; Reflux; Inert atmosphere;

2,6-dichloropyridine; With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1021/jacs.7b06997

Reference yield: 43.0%

2,6-Dibromopyridine (626-05-1) + propylzinc bromide (156567-57-6) → 2,6-di-n-propylpyridine (33354-88-0)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ja076570h

Reference yield: 39.0%

propyl cyanide (109-74-0) + hex-3-yne (928-49-4) → 2,6-di-n-propylpyridine (33354-88-0) + 1,2,3,4-tetraethylbenzene (642-32-0)

Guidance literature:

Cp₂TiCl₂; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

hex-3-yne; In tetrahydrofuran; hexane; at -10 ℃; for 3h;

propyl cyanide; In tetrahydrofuran; hexane; for 1h; Heating;

DOI:10.1021/ja027234y

upstream raw materials:

2,6-dimethylpyridine

2,6-dipropionyl-pyridine

propyl cyanide

hex-3-yne