1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine
CAS No.:1312018-60-2
Molecular Formula:C₁₅H₁₄N₂O₃S
Molecular Weight:302.354
Hs Code.:

Synonyms:1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

There total 9 articles about 1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312018-59-9
5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

: 98-09-9
benzenesulfonyl chloride

: 1312018-60-2
1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; at 0 ℃; for 0.0833333h;

benzenesulfonyl chloride; In dichloromethane; at 0 - 25 ℃; for 12.25h;

Reference yield:

: 211308-80-4
2-amino-3-iodo-5-nicotinic methyl ester

: 1312018-60-2
1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 0 - 25 °C

2.1: pyridine / dichloromethane / 12 h / 0 - 25 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Reflux

4.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

4.2: 12.25 h / 0 - 25 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C

6.1: thionyl chloride / dichloromethane / 2 h / 0 °C

7.1: methanol / 12 h / 20 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

8.2: 12.25 h / 0 - 25 °C

With pyridine; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 36052-24-1
methyl 6-aminonicotinoate

: 1312018-60-2
1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: iodine; silver trifluoroacetate / methanol / 72 h / 25 °C

2.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 0 - 25 °C

3.1: pyridine / dichloromethane / 12 h / 0 - 25 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Reflux

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C

7.1: thionyl chloride / dichloromethane / 2 h / 0 °C

8.1: methanol / 12 h / 20 °C

9.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

9.2: 12.25 h / 0 - 25 °C

With pyridine; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; iodine; silver trifluoroacetate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;