(2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

Base Information

Chemical Name:(2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile
CAS No.:1414805-54-1
Molecular Formula:C₁₉H₂₀ClN₇O₂
Molecular Weight:413.866
Hs Code.:

Synonyms:(2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

There total 11 articles about (2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1414805-55-2
[2-(1r,4r)-4-(2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

: 1414805-54-1
(2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 80 ℃; for 24h; Sealed tube;
DOI:10.1021/acs.jmedchem.9b00533

Reference yield: 96.0%

: 1414805-54-1
(2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

Guidance literature:

Reference yield:

: 22353-52-2
5-chloro-2-methoxy-3-nitropyridine

: 1414805-54-1
(2-(1r,4r)-4-{2-[(5-chloro-2-methoxypyridin-3-yl)amino]-8-oxo-7,8-dihydro-9H-purin-9-yl}cyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: zinc dibromide; hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 24 h / 100 °C / Schlenk technique; Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 80 °C / Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc dibromide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; 2: |Buchwald-Hartwig Coupling;
DOI:10.1021/acs.jmedchem.9b00533