22353-52-2

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-methoxy-3-nitropyridine is used as a key intermediate in the synthesis of various drugs. Its presence in the molecular structure allows for the development of new pharmaceutical compounds with potential therapeutic applications. 5-Chloro-2-methoxy-3-nitropyridine's functional groups facilitate chemical modifications, enabling the production of a wide range of medicinal agents.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-2-methoxy-3-nitropyridine is utilized as a building block for the development of pesticides and other crop protection agents. Its chemical properties make it suitable for the synthesis of compounds that can effectively control pests and diseases in agriculture, thereby contributing to increased crop yields and food security.
Used in Organic Synthesis:
5-Chloro-2-methoxy-3-nitropyridine is employed as a versatile building block in organic synthesis. Its nitro and chloro functional groups allow for a variety of chemical reactions, making it a valuable component in the creation of complex organic molecules. 5-Chloro-2-methoxy-3-nitropyridine is particularly useful in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including pharmaceuticals, fragrances, and flavors.
Used in Research and Development:
5-Chloro-2-methoxy-3-nitropyridine is also used in research and development settings, where it serves as a starting material for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique properties make it an attractive candidate for studying reaction mechanisms and developing new synthetic routes to biologically active molecules.

InChI:InChI=1/C6H5ClN2O3/c1-12-6-5(9(10)11)2-4(7)3-8-6/h2-3H,1H3

Upstream product

• 21427-62-3 2,5-dichloro-3-nitropyridine 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 886373-70-2 3-amino-5-chloro-2-methoxypyridine 

Relevant academic research and scientific papers

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS

Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disc

PYRIDIN-2(1H)-ONE DERIVATIVES AS JAK INHIBITORS

New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Pyridin-2(1h)-one derivatives as jak inhibitors

New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases

New pyridin-2(1h)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES

Compoundshaving the chemical structure of formula (I) are disclosed; as well as process for theirpreparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).