4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester
• CAS No.: 317318-98-2
• Molecular Formula: C₁₄H₁₂F₃NO₃
• Molecular Weight: 299.249

Synonyms:4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester

Chemical Property of 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester

There total 3 articles about 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-trifluoromethylbenzoic acid (455-24-3) → 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester (317318-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 2 h / 50 °C

2: CH₃COONH₄; CH₃COOH / 24 h / Heating

With ammonium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1055/s-2004-834862

Reference yield:

ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester (317318-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 2 h / 50 °C

2: CH₃COONH₄; CH₃COOH / 24 h / Heating

With ammonium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1055/s-2004-834862

Reference yield:

4-trifluoromethyl-benzoic acid 1-ethoxycarbonyl-2-oxo-propyl ester → 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester (317318-98-2)

Guidance literature:

With ammonium acetate; acetic acid; for 24h; Heating;

DOI:10.1055/s-2004-834862

upstream raw materials:

4-trifluoromethylbenzoic acid

ethyl 2-chloro-3-oxo-butyrate

Downstream raw materials:

[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-yl]-methanol

4-bromomethyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester

5-chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)-oxazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 317318-98-2 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send