9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen

Base Information

• Chemical Name: 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen
• CAS No.: 1325206-36-7
• Molecular Formula: C₃₃H₃₀N₂O₈
• Molecular Weight: 582.61
• Mol file: 1325206-36-7.mol

Synonyms:9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen

Chemical Property of 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen

There total 4 articles about 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

N,N-(bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)benzaldehyde (1325206-35-6) + recorcinol (108-46-3) → 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen (1325206-36-7)

Guidance literature:

With methanesulfonic acid; at 80 ℃; for 24h;

DOI:10.1021/ol201746p

Reference yield:

2-chloromethylpyridine hydrochloride (6959-47-3) → 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen (1325206-36-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride; potassium iodide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: Reflux

3.1: trichlorophosphate / 20 °C / Inert atmosphere

4.1: methanesulfonic acid / 24 h / 80 °C

With methanesulfonic acid; sodium hydride; trifluoroacetic acid; potassium iodide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol201746p

Reference yield:

[tert-butoxycarbonylmethyl-(2-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester (430459-68-0) → 9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen (1325206-36-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride; potassium iodide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: Reflux

3.1: trichlorophosphate / 20 °C / Inert atmosphere

4.1: methanesulfonic acid / 24 h / 80 °C

With methanesulfonic acid; sodium hydride; trifluoroacetic acid; potassium iodide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol201746p

upstream raw materials:

[tert-butoxycarbonylmethyl-(2-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester

N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline

N,N-(bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)benzaldehyde

recorcinol

Downstream raw materials:

C₃₀H₂₄N₂O₈

C₆₆H₈₆N₂O₁₁

C₆₂H₇₈N₂O₁₁

C₃₄H₃₂N₂O₈