N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline

Base Information

• Chemical Name: N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline
• CAS No.: 1141226-23-4
• Molecular Formula: C₂₄H₃₂N₂O₅
• Molecular Weight: 428.528
• Mol file: 1141226-23-4.mol

Synonyms:N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline

Chemical Property of N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline

There total 1 articles about N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

[tert-butoxycarbonylmethyl-(2-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester (430459-68-0) + 2-chloromethylpyridine hydrochloride (6959-47-3) → N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline (1141226-23-4)

Guidance literature:

[tert-butoxycarbonylmethyl-(2-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester; With sodium hydride; potassium iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

2-chloromethylpyridine hydrochloride; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

DOI:10.1021/ol201746p

Reference yield: 77.0%

N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline (1141226-23-4) → 4-(N,N-bis(tert-butoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)benzaldehyde (1141226-26-7)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2009.01.026

Reference yield: 47.0%

ethanol (64-17-5) + N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline (1141226-23-4) → N,N-bis(ethoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline (1325206-34-5)

Guidance literature:

N,N-bis(tert-butoxycarbonylmethyl)-2-(2-pyridylmethoxy)aniline; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

ethanol; With sulfuric acid; Reflux;

DOI:10.1021/ol201746p

upstream raw materials:

[tert-butoxycarbonylmethyl-(2-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester

2-chloromethylpyridine hydrochloride

Downstream raw materials:

4-(N,N-bis(tert-butoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)benzaldehyde

9-(4-(N,N-bis(ethoxycarbonylmethyl)amino)-3-(2-pyridylmethoxy)phenyl)-6-hydroxy-3-oxo-3H-xanthen

C₃₄H₃₂N₂O₈

C₃₀H₂₄N₂O₈