1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester

Base Information

• Chemical Name: 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester
• CAS No.: 55386-79-3
• Molecular Formula: C₁₁H₁₀O₅
• Molecular Weight: 222.197
• Mol file: 55386-79-3.mol

Synonyms:1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester

Chemical Property of 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester

There total 4 articles about 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Dimethyl oxalate (553-90-2) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester (55386-79-3)

Guidance literature:

Dimethyl oxalate; o-hydroxyacetophenone; With potassium tert-butylate; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; toluene; for 0.166667h;

Reference yield: 63.6%

acetophenone (98-86-2) + oxalic acid diethyl ester (95-92-1) → 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester (55386-79-3)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Reflux;

DOI:10.1039/c4dt03822c

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester (55386-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium ethoxide, 2.) 10percent sulphuric acid / 2.) 0 deg C, 1 h, pH 1-2

2: 42 percent Spectr_. / CDCl₃ / 20 h / 20 °C

With sulfuric acid; sodium ethanolate; In chloroform-d1;

upstream raw materials:

o-hydroxyacetophenone

Dimethyl oxalate

acetophenone

oxalic acid diethyl ester

Downstream raw materials:

methyl 5-(2-hydroxyphenyl)isoxazole-3-carboxylate

C₂₀H₁₆FNO₄

C₂₁H₁₉NO₅

C₂₃H₁₇NO₄