methyl 3-(3-aminomethylphenyl)propanoate(HCl)

Base Information

• Chemical Name: methyl 3-(3-aminomethylphenyl)propanoate(HCl)
• CAS No.: 223490-68-4
• Molecular Formula: C11H15 N O2 . Cl H
• Molecular Weight: 229.707
• Mol file: 223490-68-4.mol

Synonyms:Benzenepropanoicacid, 3-(aminomethyl)-, methyl ester, hydrochloride (9CI)

Chemical Property of methyl 3-(3-aminomethylphenyl)propanoate(HCl)

Chemical Property:

• PSA: 52.32000
• LogP: 2.75320

Purity/Quality:

95% ^*data from raw suppliers

Methyl3-(3-aminomethylphenyl)propionatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(3-aminomethylphenyl)propanoate(HCl)

There total 2 articles about methyl 3-(3-aminomethylphenyl)propanoate(HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-cyano-phenyl)-acrylic acid methyl ester (193151-10-9) → 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt (223490-68-4)

Guidance literature:

3-(3-cyano-phenyl)-acrylic acid methyl ester; With hydrogen; acetic acid; palladium 10% on activated carbon; In methanol; for 4h;

With hydrogenchloride; In methanol; diethyl ether;

Reference yield:

methyl m-bromocinnamate (79432-87-4) → 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt (223490-68-4)

Guidance literature:

Multi-step reaction with 2 steps

2: hydrogenchloride / palladium / 1,4-dioxane; methanol

With hydrogenchloride; palladium; In 1,4-dioxane; methanol;

Reference yield:

3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt (223490-68-4) + di-tert-butyl dicarbonate (24424-99-5) → methyl 3-(3-tert-butyloxycarbonylaminomethylphenyl)propionate (171662-99-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

upstream raw materials:

3-(3-cyano-phenyl)-acrylic acid methyl ester

methyl m-bromocinnamate

Downstream raw materials:

methyl 3-(3-tert-butyloxycarbonylaminomethylphenyl)propionate

3-{3-[(4-isobutyl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

3-{3-[(4-pyrazin-2-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

3-{3-[(4-thiazol-2-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

Refernces

• 1、 -. "Prostaglandin agonists and their use to treat bone disorders". . . Retrieved 2008/06/13.