2-(4-formylphenyl)-2-methylpropionic acid methyl ester

Base Information

• Chemical Name: 2-(4-formylphenyl)-2-methylpropionic acid methyl ester
• CAS No.: 84542-11-0
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 84542-11-0.mol

Synonyms:2-(4-formylphenyl)-2-methylpropionic acid methyl ester

Chemical Property of 2-(4-formylphenyl)-2-methylpropionic acid methyl ester

Chemical Property:

Purity/Quality:

Methyl2-(4-formylphenyl)-2-methylpropanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-formylphenyl)-2-methylpropionic acid methyl ester

There total 8 articles about 2-(4-formylphenyl)-2-methylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 2-bromo-4-(bromomethyl)benzoate (128577-48-0) → 2-(4-formylphenyl)-2-methylpropionic acid methyl ester (84542-11-0)

Guidance literature:

With sodium hydrogencarbonate; dimethyl sulfoxide; at 120 ℃; for 3h;

Reference yield: 80.0%

p-bromobenzaldehyde 1,3-dioxolane (10602-01-4) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) → 2-(4-formylphenyl)-2-methylpropionic acid methyl ester (84542-11-0)

Guidance literature:

Methyl isobutyrate; With lithium dicyclohexylamide; In toluene; for 0.166667h;

p-bromobenzaldehyde 1,3-dioxolane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In toluene;

With pyridinium p-toluenesulfonate; In water; acetone;

Reference yield:

Dichloromethyl methyl ether (4885-02-3) + methyl 2-methyl-2-phenylpropionate (57625-74-8) → 2-(4-formylphenyl)-2-methylpropionic acid methyl ester (84542-11-0)

Guidance literature:

titanium tetrachloride; In dichloromethane; at 0 - 20 ℃; for 16.25h;

upstream raw materials:

methyl 2-bromo-4-(bromomethyl)benzoate

zinc(II) cyanide

methyl 2-methyl-2-phenylpropionate

2-(4-hydroxymethylphenyl)-2-methylpropionic acid methyl ester

Downstream raw materials:

4-(2-methoxy-1,1-dimethyl-2-oxoethyl)benzoic acid