2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Base Information

• Chemical Name: 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide
• CAS No.: 81165-22-2
• Molecular Formula: C₁₈H₁₉Cl₂NO₃
• Molecular Weight: 368.26
• Mol file: 81165-22-2.mol

Synonyms:2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Chemical Property of 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

There total 1 articles about 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,4-dichlorophenyl acetic acid (5807-30-7) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide (81165-22-2)

Guidance literature:

With potassium carbonate; In acetonitrile; for 6h; Heating;

DOI:10.1002/jhet.5570360507

Reference yield: 82.0%

2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide (81165-22-2) → 1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline (258520-82-0)

Guidance literature:

With trichlorophosphate; In toluene; for 4h; Heating;

DOI:10.1002/jhet.5570360507

Reference yield:

2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide (81165-22-2) → 1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline (81165-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / POCl₃ / toluene / 4 h / Heating

2: 90 percent / NaBH₄ / methanol / 8 h / 20 °C

With sodium tetrahydroborate; trichlorophosphate; In methanol; toluene; 1: Cyclization / 2: Reduction;

DOI:10.1002/jhet.5570360507

upstream raw materials:

3,4-dichlorophenyl acetic acid

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

C₄₆H₅₄Cl₄N₂O₈⁽²⁺⁾*2CH₃O₃S^(1-)

3-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 2-{3-[1-(3,4-dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-ethyl ester; compound with oxalic acid