D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

Base Information

Chemical Name:D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester
CAS No.:854371-76-9
Molecular Formula:C₃₀H₃₃NO₆S
Molecular Weight:535.661
Hs Code.:

Synonyms:D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

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Chemical Property of D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

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Technology Process of D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

There total 8 articles about D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 854371-75-8
2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxymethyl]benzofuran

: 779341-90-1
(R)-2-(4-bromobenzenesulfonylamino)-3-methylbutyric acid tert-butyl ester

: 854371-76-9
D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 8h;
DOI:10.1016/j.bmc.2005.07.076

Reference yield: 33.0%

: 854371-76-9
D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

Guidance literature:

Reference yield:

: 41014-27-1
2-bromomethylbenzofuran

: 854371-76-9
D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / K₂CO₃ / acetonitrile / 16 h / 70 °C

2: 33 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 8 h / 90 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2005.07.076