N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide
CAS No.:1262860-28-5
Molecular Formula:C₂₀H₃₃BrF₃NO₂SSi
Molecular Weight:516.538
Hs Code.:

Synonyms:N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

There total 7 articles about N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1262860-26-3
N-(1-(5-bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropylidene)-2-methylpropane-2-sulfinamide

: 75-16-1
methylmagnesium bromide

: 1262860-28-5
N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: In diethyl ether; at -25 - 0 ℃;

Reference yield:

: CH₃MgBr

: N-(1-(5-bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropylidene)-2-methylpropane-2-sulfinamide

: 1262860-28-5
N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: With ammonium chloride; In diethyl ether; hexane; ethyl acetate;

Reference yield:

: 93777-26-5
5-bromo-2-fluorobenzaldehyde

: 1262860-28-5
N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethyl acetate; N,N-dimethyl-formamide; hexane

2: ammonium chloride; sodium tetrahydroborate / ethyl acetate; hexane; methanol

3: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

4: dichloromethane; ethyl acetate; hexane

5: ethyl acetate; hexane; tetrahydrofuran

6: ammonium chloride / ethyl acetate; hexane; diethyl ether

With sodium tetrahydroborate; ammonium chloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;