dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

Base Information

Chemical Name:dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate
CAS No.:270064-54-5
Molecular Formula:C₂₅H₂₀N₂O₁₀
Molecular Weight:508.441
Hs Code.:

Synonyms:dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

Suppliers and Price of dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

There total 5 articles about dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.9%

: 122-04-3
4-nitro-benzoyl chloride

: 100596-38-1
dimethyl 5-[3-amino-4-methoxycarbonylphenoxy]isophthalate

: 270064-54-5
dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

Guidance literature:: With triethylamine; In chloroform; at 20 ℃;
DOI:10.1016/S0968-0896(01)00023-2

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 270064-54-5
dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: H₂ / 10 percent Pd/C / methanol; dioxane / 20 °C / 2280 Torr

3: Et₃N / CHCl₃ / 20 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; 1: Etherification / 2: Catalytic hydrogenation / 3: Acylation;
DOI:10.1021/jm990342j

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 270064-54-5
dimethyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]isophthalate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: H₂ / 10 percent Pd/C / methanol; dioxane / 20 °C / 2280 Torr

3: Et₃N / CHCl₃ / 20 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; 1: Etherification / 2: Catalytic hydrogenation / 3: Acylation;
DOI:10.1021/jm990342j