3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

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Chemical Name:3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine
CAS No.:1080623-54-6
Molecular Formula:C₇₃H₇₅N₅O₁₅Si
Molecular Weight:1290.51
Hs Code.:

3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

Synonyms:3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

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Chemical Property of 3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

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Technology Process of 3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

There total 1 articles about 3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1080623-53-5
3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

: 192653-09-1
3-N-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)thymidine

: 1080623-54-6
3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

Guidance literature:: 3-N-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)thymidine; With sodium hydride; In tetrahydrofuran; for 0.5h; Cooling with ice; Inert atmosphere;

3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine; In tetrahydrofuran; for 3h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.073

Reference yield:

: 1080623-54-6
3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

: 1138083-44-9
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

Guidance literature:: 3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine; With boron trichloride; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

With pyridine; 4,4'-dimethoxytrityl chloride; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.073