3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

Base Information

Chemical Name:3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine
CAS No.:1080623-53-5
Molecular Formula:C₄₀H₄₀N₄O₁₀Si
Molecular Weight:764.864
Hs Code.:

Synonyms:3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

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Chemical Property of 3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

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Technology Process of 3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

There total 1 articles about 3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1080623-52-4,1138083-38-1
(2S,8R,10R,12S)-5-(benzyloxymethyl)-11-(tert-butyldiphenylsilyloxy)-9,13-dioxa-1,5,7-triazatetracyclo[8.3.1.0(2,7).0(8,12)]tetradecane-4,6-dione

: 7693-46-1
4-Nitrophenyl chloroformate

: 1080623-53-5
3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; tetra-(n-butyl)ammonium iodide; In o-xylene; for 66h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.073

Reference yield: 87.0%

: 1080623-53-5
3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine

: 192653-09-1
3-N-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)thymidine

: 1080623-54-6
3-N-benzyloxymethyl-5'-O-dimethoxytritylthymidylyl-(3'-5'-carbamoyl)-5'-amino-3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

Guidance literature:: 3-N-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)thymidine; With sodium hydride; In tetrahydrofuran; for 0.5h; Cooling with ice; Inert atmosphere;

3-N-benzyloxymethyl-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxy-(4-nitrophenoxy)carbonylaminoarabinouridine; In tetrahydrofuran; for 3h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.073