(Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

Base Information

Chemical Name:(Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene
CAS No.:1276045-72-7
Molecular Formula:C₂₁H₂₆O₄
Molecular Weight:342.435
Hs Code.:

Synonyms:(Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

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Technology Process of (Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

There total 5 articles about (Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 64-17-5
ethanol

: 52999-15-2
4-(p-methoxyphenyl)-3-butyn-1-ol

: 80778-47-8
1-iodo-2-methoxymethoxybenzene

: 1276045-72-7
(Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

Guidance literature:: ethanol; 4-(p-methoxyphenyl)-3-butyn-1-ol; With toluene-4-sulfonic acid; at 120 ℃; for 0.5h; Microwave irradiation;

With toluene-4-sulfonic acid hydrazide; at 50 ℃; for 0.25h; Microwave irradiation;

1-iodo-2-methoxymethoxybenzene; With dichloro bis(acetonitrile) palladium(II); lithium tert-butoxide; XPhos; In 1,4-dioxane; at 90 ℃; for 1h; optical yield given as %de; stereoselective reaction;
DOI:10.1016/j.tetlet.2010.12.093

Reference yield:

: C₂₀H₂₆N₂O₄S

: 80778-47-8
1-iodo-2-methoxymethoxybenzene

: 1276045-72-7
(Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); lithium tert-butoxide; XPhos; In 1,4-dioxane; at 90 ℃; for 1h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201101735

Reference yield:

: 52999-15-2
4-(p-methoxyphenyl)-3-butyn-1-ol

: 1276045-72-7
(Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

2: 0.25 h / 50 °C / Microwave irradiation; Inert atmosphere

3: dichloro bis(acetonitrile) palladium(II); lithium tert-butoxide; XPhos / 1,4-dioxane / 1 h / 90 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); toluene-4-sulfonic acid; lithium tert-butoxide; XPhos; In 1,4-dioxane;
DOI:10.1002/ejoc.201101735