(E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

Base Information

Chemical Name:(E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate
CAS No.:953434-85-0
Molecular Formula:C₂₅H₂₄N₂O₄S
Molecular Weight:448.543
Hs Code.:

Synonyms:(E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

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Chemical Property of (E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

Chemical Property:

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Technology Process of (E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

There total 1 articles about (E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 335255-43-1
tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

: 639784-89-7
(E)-3-(4-formylphenyl)acrylic acid chloride

: 953434-85-0
(E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

Guidance literature:: With pyridine; dmap; In 1,2-dichloro-ethane; at 20 ℃; for 72h;

Reference yield: 100.0%

: 110-91-8,99108-56-2
morpholine

: 953434-85-0
(E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

: 953434-86-1
(E)-tert-butyl 2-(3-(4-(morpholinomethyl)phenyl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

Guidance literature:: morpholine; (E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate; With dibutyltin chloride; In 1,2-dimethoxyethane; for 0.25h;

With phenylsilane; In 1,2-dimethoxyethane; at 20 ℃; for 15h;

With methanol; In 1,2-dimethoxyethane; for 3h;

Reference yield:

: 6165-68-0
thiophene boronic acid

: iron(III) chloride

: 335255-43-1
tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

: 335254-95-0
tert-butyl (2-nitro-4-(thiophen-2-yl) phenyl)carbamate

: 953434-85-0
(E)-tert-butyl 2-(3-(4-formylphenyl)acrylamido)-4-(thiophen-2-yl)phenyl-carbamate

: 327046-79-7
tert-butyl (4-bromo-2-nitrophenyl)carbamate

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1001-53-2
monoacetylaminoethylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 875-51-4
4-Bromo-2-nitroaniline

: triacetoxylpalladium

: 14990-09-1
tert-butyl cinnamate

: 1122-91-4
4-bromo-benzaldehyde

: 66885-68-5
(E)-p-formylcinnamic acid

: 6163-58-2
tris-(o-tolyl)phosphine

: 1228793-70-1
BRD-9460

Guidance literature:: With hydrogenchloride; NaBH(OAc)3; NaH; DIPEA; sodium hydrogencarbonate; sodium carbonate; hydrazine hydrate; ethylenediamine; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 1,1-dichloroethane; water; ethyl acetate; N,N-dimethyl-formamide;