5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Base Information

Chemical Name:5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.:222631-45-0
Molecular Formula:C₂₄H₄₀N₄O₅Si
Molecular Weight:492.691
Hs Code.:

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Synonyms:5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Suppliers and Price of 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

There total 7 articles about 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6011-14-9
2-aminoacetonitrile hydrochloride

: 284490-14-8
(1S)-N-tert-butoxycarbonyl-5-O-tert-butyldimethylsilyl-1-C-(1-cyano-2-hydroxyethenyl)-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol

: 222631-45-0
4-(tert-butyl-dimethyl-silanyloxymethyl)-6-[1-cyano-2-(cyanomethyl-amino)-vinyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: With sodium acetate; In methanol; at 20 ℃; for 16h;
DOI:10.1016/S0040-4020(00)00194-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 222631-45-0
4-(tert-butyl-dimethyl-silanyloxymethyl)-6-[1-cyano-2-(cyanomethyl-amino)-vinyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CH₂Cl₂ / 16 h / 20 °C

2: dimethylformamide / 1 h / 65 - 70 °C

3: 0.68 g / aq. AcOH / tetrahydrofuran / 1.5 h / 20 °C

4: NaOAc / methanol / 16 h / 20 °C

With sodium acetate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Hydrolysis / 4: Condensation;
DOI:10.1016/S0040-4020(00)00194-0

Reference yield:

: 153172-31-7
(3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole

: 222631-45-0
4-(tert-butyl-dimethyl-silanyloxymethyl)-6-[1-cyano-2-(cyanomethyl-amino)-vinyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NCS / pentane / 1 h

1.2: LiTMP / tetrahydrofuran / -78 °C

2.1: 0.83 g / tetrahydrofuran / 1 h / -78 °C

3.1: 85 percent / CH₂Cl₂ / 16 h / 20 °C

4.1: dimethylformamide / 1 h / 65 - 70 °C

5.1: 0.68 g / aq. AcOH / tetrahydrofuran / 1.5 h / 20 °C

6.1: NaOAc / methanol / 16 h / 20 °C

With N-chloro-succinimide; sodium acetate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; pentane; 1.1: Chlorination / 1.2: Elimination / 2.1: Addition / 3.1: Substitution / 4.1: Condensation / 5.1: Hydrolysis / 6.1: Condensation;
DOI:10.1016/S0040-4020(00)00194-0