1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

Base Information

Chemical Name:1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea
CAS No.:1623153-49-0
Molecular Formula:C₂₂H₂₄FN₅OS
Molecular Weight:425.53
Hs Code.:

Synonyms:1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

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Chemical Property of 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

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Technology Process of 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

There total 6 articles about 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 959617-72-2
1-(2-(4-aminopiperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one

: 103-72-0
phenyl isothiocyanate

: 1623153-49-0
1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2014.08.018

Reference yield:

: 884495-37-8
2-chloro-5-fluoro-3-nitropyridine

: 1623153-49-0
1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

Guidance literature:: Multi-step reaction with 6 steps

1: N-Methyldicyclohexylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; palladium diacetate / 4 h / 150 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Sealed tube

3: dichloromethane; pyridine / 0.5 h / -20 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Sealed tube

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C

6: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; N-Methyldicyclohexylamine; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In 1,4-dioxane; pyridine; dichloromethane; N,N-dimethyl-formamide; 1: |Heck Reaction;
DOI:10.1016/j.ejmech.2014.08.018

Reference yield:

: 959615-64-6
7-fluoro-1,5-naphthyridin-2(1H)-one

: 1623153-49-0
1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Sealed tube

2: dichloromethane; pyridine / 0.5 h / -20 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Sealed tube

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C

5: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; potassium carbonate; caesium carbonate; triethylamine; In 1,4-dioxane; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.08.018