5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Base Information

Chemical Name:5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide
CAS No.:1454667-68-5
Molecular Formula:C₁₉H₁₄BrF₄N₃O₂S₂
Molecular Weight:536.369
Hs Code.:

Synonyms:5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Chemical Property of 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Technology Process of 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

There total 5 articles about 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454667-12-9
5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1454667-30-1
N-(5-fluorothiazol-2-yl)-1H-imidazole-1-sulfonamide

: 1454667-68-5
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 80 ℃; for 0.5h;

Reference yield:

: 1454667-10-7
tert-butyl 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1454667-68-5
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 80 °C

With methanol; triethylamine; acetyl chloride; In tetrahydrofuran;

Reference yield:

: 481075-58-5
2-bromo-1-iodo-4-(trifluoromethyl)benzene

: 1454667-68-5
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; 1,4-dioxane / 100 °C

1.2: 3 h / 130 °C / Microwave irradiation

2.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

3.1: triethylamine / tetrahydrofuran / 0.5 h / 80 °C

With methanol; potassium carbonate; triethylamine; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; water;