2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

Base Information

Chemical Name:2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one
CAS No.:264608-76-6
Molecular Formula:C₂₆H₂₀N₆O₂
Molecular Weight:448.484
Hs Code.:

Synonyms:2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

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Chemical Property of 2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

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Technology Process of 2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

There total 6 articles about 2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 37156-84-6
4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol

: 264608-82-4
3-(p-azidophenyl)-2-oxopropanal

: 264608-76-6
2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

Guidance literature:: With hydrogenchloride; In ethanol; at 55 ℃; for 8h;
DOI:10.1246/bcsj.73.465

Reference yield:

: 62893-37-2
2-(4-azidophenyl)acetic acid

: 264608-76-6
2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / benzene / 18 h / 20 °C

2: 5.0 g / diethyl ether / 1 h / 0 °C

3: 90 percent / HBr / diethyl ether / 0.33 h / 0 °C

4: 86 percent / AgNO₃ / acetonitrile / 28 h / 20 °C

5: 100 percent / sodium acetate trihydrate / dimethylsulfoxide / 1 h / 20 °C

6: 55 percent / aq. HCl / ethanol / 8 h / 55 °C

With hydrogenchloride; thionyl chloride; hydrogen bromide; sodium acetate; silver nitrate; In diethyl ether; ethanol; dimethyl sulfoxide; acetonitrile; benzene; 1: Substitution / 2: Acylation / 3: Substitution / 4: Substitution / 5: Oxidation / 6: Cyclization;
DOI:10.1246/bcsj.73.465

Reference yield:

: 247150-03-4
2-(4-azidophenyl)acetyl chloride

: 264608-76-6
2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 5.0 g / diethyl ether / 1 h / 0 °C

2: 90 percent / HBr / diethyl ether / 0.33 h / 0 °C

3: 86 percent / AgNO₃ / acetonitrile / 28 h / 20 °C

4: 100 percent / sodium acetate trihydrate / dimethylsulfoxide / 1 h / 20 °C

5: 55 percent / aq. HCl / ethanol / 8 h / 55 °C

With hydrogenchloride; hydrogen bromide; sodium acetate; silver nitrate; In diethyl ether; ethanol; dimethyl sulfoxide; acetonitrile; 1: Acylation / 2: Substitution / 3: Substitution / 4: Oxidation / 5: Cyclization;
DOI:10.1246/bcsj.73.465