3-(3-(4-((Pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine

Base Information

Chemical Name:3-(3-(4-((Pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine
CAS No.:936339-60-5
Molecular Formula:C₂₁H₁₈N₄O₂
Molecular Weight:358.4
Hs Code.:
European Community (EC) Number:811-768-9
UNII:7B1P18ID9L
ChEMBL ID:CHEMBL4533578
DSSTox Substance ID:DTXSID601045473
Nikkaji Number:J2.858.841K
Wikidata:Q15410951
Wikipedia:E1210,Manogepix

Synonyms:3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine;APX001A;E1210;Manogepix

Suppliers and Price of 3-(3-(4-((Pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of 3-(3-(4-((Pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:358.14297583
Heavy Atom Count:27
Complexity:444

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C(N=CC=C4)N
Recent ClinicalTrials:A Bioequivalence Study of APX001 High-load and Low-load Tablets

Technology Process of 3-(3-(4-((Pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine

There total 14 articles about 3-(3-(4-((Pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

: 1075734-33-6
di-tert-butyl (3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-yl)imidodicarbonate

: 144-55-8
sodium hydrogencarbonate

: 1310-73-2
sodium hydroxide

: 936339-60-5
3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine

Guidance literature:: di-tert-butyl (3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-yl)imidodicarbonate; With formic acid; In toluene; at -5 - 32 ℃;

sodium hydroxide; In water; at 0 - 25 ℃;

sodium hydrogencarbonate; In water; ethyl acetate; at 20 - 30 ℃; for 1h; Product distribution / selectivity;