1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone
CAS No.:1609655-23-3
Molecular Formula:C₂₃H₂₈F₃N₃O₂
Molecular Weight:435.489
Hs Code.:

Synonyms:1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

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Chemical Property of 1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

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Technology Process of 1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

There total 4 articles about 1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13889-98-0
N-acetylpiperidine

: 1609654-73-0
5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

: 1609655-23-3
1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609655-23-3
1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

3.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

4.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With bromine; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; 2.1: |Duff Aldehyde Synthesis / 3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;

Reference yield:

: 2198-66-5
2-bromo-4-tert-butylphenol

: 1609655-23-3
1-(4-(5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

2.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

3.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: |Duff Aldehyde Synthesis / 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling;