Technology Process of methyl 4-[(1E)-4-(adamant-1-yl)but-1-en-1-yl]benzoate
There total 11 articles about methyl 4-[(1E)-4-(adamant-1-yl)but-1-en-1-yl]benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl (4-carbomethoxybenzyl)phosphonate;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
3-(1-adamantyl)propanal;
In
tetrahydrofuran;
at 0 - 5 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sulfuric acid / 3 h / 80 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h / 0 - 20 °C
3.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
4.2: 1 h / 0 - 5 °C
5.1: sodium hydroxide; water / methanol / 2 h / 70 °C
5.2: 0.5 h / 4 °C / pH 2
6.1: hydrogen / palladium 10% on activated carbon / methanol / 0.25 h / 2068.65 Torr
7.1: sulfuric acid / 3 h / 80 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h / 0 - 20 °C
9.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
10.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
10.2: 1 h / 0 - 5 °C
With
lithium aluminium tetrahydride; sulfuric acid; water; hydrogen; sodium hydride; pyridinium chlorochromate; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
2.2: 1 h / 0 - 5 °C
3.1: sodium hydroxide; water / methanol / 2 h / 70 °C
3.2: 0.5 h / 4 °C / pH 2
4.1: hydrogen / palladium 10% on activated carbon / methanol / 0.25 h / 2068.65 Torr
5.1: sulfuric acid / 3 h / 80 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h / 0 - 20 °C
7.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
8.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
8.2: 1 h / 0 - 5 °C
With
lithium aluminium tetrahydride; sulfuric acid; water; hydrogen; sodium hydride; pyridinium chlorochromate; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane;