N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine

Base Information

• Chemical Name: N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine
• CAS No.: 1305317-10-5
• Molecular Formula: C₃₄H₂₆N₄O₂
• Molecular Weight: 522.606
• Mol file: 1305317-10-5.mol

Synonyms:N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine

Chemical Property of N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine

There total 6 articles about N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

Benzophenone imine (1013-88-3) + 8-bromo-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine (1305317-08-1) → N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine (1305317-10-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate; In toluene; at 100 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1259429

Reference yield:

4-aminopyridine (504-24-5) → N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine (1305317-10-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 5.5 h / 10 - 20 °C

2.1: sulfuric acid / 20 - 90 °C

3.1: potassium acetate; acetic acid / 1 h / 20 °C

3.2: 20 °C

4.1: water; tin(ll) chloride / ethanol / 2 h / Reflux

5.1: 1,4-dioxane / Reflux

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sulfuric acid; water; nitric acid; potassium acetate; acetic acid; tin(ll) chloride; sodium t-butanolate; In 1,4-dioxane; ethanol; toluene; 6.1: Buchwald reaction;

DOI:10.1055/s-0030-1259429

Reference yield:

3,4-diamino-5-bromopyridine (4635-08-9) → N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine (1305317-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate; In 1,4-dioxane; toluene; 2: Buchwald reaction;

DOI:10.1055/s-0030-1259429

upstream raw materials:

4-aminopyridine

Benzophenone imine

8-bromo-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine

3,4-diamino-5-bromopyridine

Downstream raw materials:

8-amino-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine

8-amino-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine hydrochloride

N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea

N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-ethylthiourea