2-CHLORO-3-METHOXYBENZALDEHYDE

Base Information

• Chemical Name: 2-CHLORO-3-METHOXYBENZALDEHYDE
• CAS No.: 54881-49-1
• Molecular Formula: C8H7ClO2
• Molecular Weight: 170.595
• Hs Code.: 2913000090
• Mol file: 54881-49-1.mol

Synonyms:2-CHLORO-3-METHOXYBENZALDEHYDE,98.0+%(GC)

Chemical Property of 2-CHLORO-3-METHOXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Melting Point: 56-60 °C(lit.)
• Refractive Index: 1.564
• Boiling Point: 260℃
• Flash Point: 115℃
• PSA: 26.30000
• Density: 1.244
• LogP: 2.16110

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-36/37/38-50
• Safety Statements: 26-36-45-60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-CHLORO-3-METHOXYBENZALDEHYDE

There total 5 articles about 2-CHLORO-3-METHOXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-3-hydroxybenzaldehyde (56962-10-8) + methyl iodide (74-88-4) → 2-chloro-3-methoxy benzaldehyde (54881-49-1)

Guidance literature:

2-chloro-3-hydroxybenzaldehyde; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00163

Reference yield: 87.0%

2-chloro-3-hydroxybenzaldehyde (56962-10-8) + dimethyl sulfate (77-78-1) → 2-chloro-3-methoxy benzaldehyde (54881-49-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1071/CH05120

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → 2-chloro-3-methoxy benzaldehyde (54881-49-1)

Guidance literature:

With n-butyllithium; N,N',N'-trimethylenediamine; In toluene; at 0 ℃; for 0.25h;

3-methoxy-benzaldehyde; In toluene; at 0 ℃; for 0.5h;

With hexachloroethane; phenyllithium; more than 3 stages;

upstream raw materials:

2-chloro-3-methoxybenzyl alcohol

2-chloro-3-methoxybenzoic acid

2-chloro-3-hydroxybenzaldehyde

dimethyl sulfate

Downstream raw materials:

2'-Chlor-3'-hydroxybutyrophenon

2-Chlor-3-butyryl-phenoxyessigsaeure

2-chloro-1-methoxy-3-(2-nitrovinyl)benzene

7-methoxy-1H-indazole

Refernces

• 1、 Giles, Robin G. F.,Green, Ivan R.,Li, Shuk-Hui. "Stereoselective isomerizations of 4-(2′-chloro-3′-methoxyphenyl)-2,5-dimethyl-1,3-dioxolanes: Stereochemistry and conformation of the product 2-benzopyrans". . p. 565 - 571. Retrieved 2005.
• 2、 -. "ALKOXY PYRAZOLES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS". Paragraph 0116; 0117. . Retrieved 2014/03/25.