Technology Process of N-(10-{4-[(4-butylphenyl)diazenyl]phenoxy}decanoyl)aspartic acid dimethyl ester
There total 5 articles about N-(10-{4-[(4-butylphenyl)diazenyl]phenoxy}decanoyl)aspartic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
10-{4-[(4-butylphenyl)diazenyl]phenoxy}decanoic acid;
With
1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; ethyl acetate;
at 20 ℃;
for 1h;
Inert atmosphere;
dimethyl L-aspartate hydrochloride;
In
tetrahydrofuran; ethyl acetate;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/la3030606
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 1 h / 20 °C
1.2: 5 °C
1.3: 3 h / 5 °C
2.1: potassium carbonate; potassium iodide / acetone / 24 h / Inert atmosphere; Reflux
3.1: water; potassium hydroxide / tetrahydrofuran / Inert atmosphere; Reflux
4.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran; ethyl acetate / 1 h / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; potassium hydroxide;
In
tetrahydrofuran; water; ethyl acetate; acetone;
2.1: |Williamson Ether Synthesis;
DOI:10.1021/la3030606
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 1 h / 20 °C
1.2: 5 °C
1.3: 3 h / 5 °C
2.1: potassium carbonate; potassium iodide / acetone / 24 h / Inert atmosphere; Reflux
3.1: water; potassium hydroxide / tetrahydrofuran / Inert atmosphere; Reflux
4.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran; ethyl acetate / 1 h / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; potassium hydroxide;
In
tetrahydrofuran; water; ethyl acetate; acetone;
2.1: |Williamson Ether Synthesis;
DOI:10.1021/la3030606
![10-{4-[(4-butylphenyl)diazenyl]phenoxy}decanoic acid](/Databaselist/images/loading.webp)
