32213-95-9Relevant articles and documents
Antioxidant activity, synthesis and characterization of Schiff base ligand 'asasp' and metal complexes
Ozdemir, Mecit,Sonmez, Mehmet
, p. 7009 - 7015 (2014)
In the present work, the synthesis and structural characterization of a novel Schiff base ligand derived from 2-acetyl pyridine and L-aspartic acid dimethyl ester and its metal complexes have been reported. All the synthesized compounds were characterized by using various spectral techniques like ESI-MS, FT-IR, 1H NMR, 13C NMR, UV-visible spectra, elemental analysis and ICP-OES analyses. The ligand and metal ions reacted to form in the 2:1 or 1:1 (M:L) ratio as found from the elemental analyses and the general stoichiometry was determined [L(Cu)2(AcO)4] and [LM(H2O)2]2Cl·nH2O where M = Co(II), Ni(II), Ni(II) and L = asasp and n = 1 or 2. On the basis of nalytical data, a possible structure for the copper(II) complex is tetrahedral and those for the Co(II), Ni(II) and Mn(II) complexes are ctahedral. The ligand and its metal complexes were tested for their possible antioxidant potentials. Comparison of antioxidant assays ere investigated by using two reference molecules, vitamin C and quercetin. The complexes showed significant activities in these in vitro ntioxidant assays compared to the reference (quercetin and vitamin C) and Ni(II)-complex exhibited a promising antioxidant activity.
Ribose conversion with amino acids into pyrraline platform chemicals-expeditious synthesis of diverse pyrrole-fused alkaloid compounds
Cho, Soohyeon,Gu, Lina,In, Ik Joon,Kim, Hakwon,Koo, Sangho,Lee, Taehoon,Wu, Bo
, p. 31511 - 31525 (2021/11/30)
One-pot conversion of sustainable d-ribose with l-amino acid, methyl esters produced pyrrole-2-carbaldehydes 5 in reasonable yields (32-63%) under pressurized conditions of 2.5 atm at 80 °C. The value-added pyrraline compounds 5 as platform chemicals were utilized for quick installation of poly-heterocyclic cores for the development of pyrrole-motif natural and artificial therapeutic agents. A pyrrole-fused piperazin-2-one scaffold 6 was prepared by reductive amination of pyrralines 5 with benzylamine. While further cyclization of pyrralines 5 with ethane-1,2-diamine produced pyrrolo-piperazin-2-ones 7 with an extra imidazolidine ring, the reaction with 2-amino alcohols derived from natural l-amino acids, alanine, valine, and phenylalanine, respectively provided pyrrolo-piperazin-2-ones 8, 9, and 10 with oxazolidine as the third structural core. Cell viability and an anti-inflammatory effect of the synthesized compounds were briefly tested by the MTT method and the Griess assay, among which 8h and 10g exhibited significant anti-inflammatory effects with negligible cell toxicity.
Conformationally rigid pyrazoloquinazoline α-amino acids: One- And two-photon induced fluorescence
Bell, Jonathan D.,Harkiss, Alexander H.,Nobis, David,Malcolm, Eilidh,Knuhtsen, Astrid,Wellaway, Christopher R.,Jamieson, Andrew G.,Magennis, Steven W.,Sutherland, Andrew
supporting information, p. 1887 - 1890 (2020/02/22)
The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demonstration of two-photon-induced fluorescence via near-IR excitation signifies their potential for sensitive bioimaging applications.
