N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

Base Information

Chemical Name:N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester
CAS No.:913730-63-9
Molecular Formula:C₁₈H₂₆N₂O₆S₂
Molecular Weight:430.546
Hs Code.:

Synonyms:N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

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Chemical Property of N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

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Technology Process of N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

There total 1 articles about N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5335-40-0
3-(methylsulfonyl)benzenesulfonyl chloride

: 913730-63-9
N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

Guidance literature:: 1-(tert-butyl) 2-methyl (2S,4R)-4-(piperidin-1-yl)pyrrolidine-1,2-dicarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

3-(methylsulfonyl)benzenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 913730-63-9
N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

: 913730-64-0
C₁₇H₂₄N₂O₆S₂

Guidance literature:: N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester; With lithium hydroxide; water; In acetonitrile; at 20 ℃; for 0.5h;

With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 913730-63-9
N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-L-proline methyl ester

: N-{N-[(3-methylsulfonylbenzene)sulfonyl]-4(R)-piperidino-(L)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / acetonitrile / 0.5 h / 20 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

3: lithium hydroxide; water / acetonitrile / 0.5 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; water; HATU; In N,N-dimethyl-formamide; acetonitrile;