methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

Base Information

• Chemical Name: methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate
• CAS No.: 174956-23-1
• Molecular Formula: C₃₇H₅₃N₃O₈Si
• Molecular Weight: 695.929

Synonyms:methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

Chemical Property of methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Useful:

Technology Process of methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

There total 23 articles about methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanol (67-56-1) + (2S,8S)-4-(benzyloxy)-3,6-bis(tert-butyloxycarbonyl)-8-[(tert-butyldimethylsilyl)oxy]-1-imino-2-methyl-2-[[(4S)-2-oxo-4-isopropyloxazolidin-3-yl]carbonyl]-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline (174956-25-3) → methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate (174956-23-1)

Guidance literature:

With lithium methanolate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/ja953777e

Reference yield:

methanol (67-56-1) + (2S,8S)-4-(benzyloxy)-3,6-bis(tert-butyloxycarbonyl)-8-[(tert-butyldimethylsilyl)oxy]-1-imino-2-methyl-2-[[(4R)-2-oxo-4-isopropyloxazolidin-3-yl]carbonyl]-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline (174956-26-4) → methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate (174956-23-1)

Guidance literature:

With lithium methanolate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/ja953777e

Reference yield:

methyl 2-[N-(tert-butyloxycarbonyl)-N-[7-(benzyloxy)-3(S)-[(tert-butyldimethylsilyl)oxy]-1-(tert-butyloxycarbonyl)-5-cyano-1,2,3,4-tetrahydroquinolin-6-yl]amino]propionate → methyl (2S,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate (174956-23-1) + methyl (2R,8S)-4-(benzyloxy)-8-[(tert-butyldimethylsilyl)oxy]-3,6-bis(tert-butyloxycarbonyl)-1-imino-2-methyl-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate (174873-33-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/ja962431g

upstream raw materials:

methanol

(2S,8S)-4-(benzyloxy)-3,6-bis(tert-butyloxycarbonyl)-8-[(tert-butyldimethylsilyl)oxy]-1-imino-2-methyl-2-[[(4S)-2-oxo-4-isopropyloxazolidin-3-yl]carbonyl]-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline

(2S,8S)-4-(benzyloxy)-3,6-bis(tert-butyloxycarbonyl)-8-[(tert-butyldimethylsilyl)oxy]-1-imino-2-methyl-2-[[(4R)-2-oxo-4-isopropyloxazolidin-3-yl]carbonyl]-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline

(3S)-7-(benzyloxy)-3-[(tert-butyldimethylsilyl)oxy]-1-(tert-butyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-cyano-1,2,3,4-tetrahydroquinoline

Downstream raw materials:

methyl (2S,8S)-4-(benzyloxy)-8-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

methyl (2S,8S)-4-(benzyloxy)-8-[(methanesulfonyl)oxy]-2-methyl-1-oxo-6-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

methyl (2S,8S)-4-(benzyloxy)-6-(tert-butyloxycarbonyl)-8-hydroxy-2-methyl-1-oxo-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

methyl (2S,8S)-4-(benzyloxy)-6-(tert-butyloxycarbonyl)-8-[(methanesulfonyl)oxy]-2-methyl-1-oxo-2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylate

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