ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Base Information

Chemical Name:ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate
CAS No.:1338566-13-4
Molecular Formula:C₃₃H₄₈O₇Si
Molecular Weight:584.825
Hs Code.:

Synonyms:ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Suppliers and Price of ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

There total 10 articles about ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1338566-12-3
ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-hydroxyoctahydropyrano[3,2-b]pyran-2-yl)acetate

: 69739-34-0
t-butyldimethylsiyl triflate

: 1338566-13-4
ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/jo302267f

Reference yield:

: 1338566-08-7
(2S,3R,5S,6R)-5-(benzyloxy)-6-((benzyloxy)methyl)-2-((1,3-dithian-2-yl)methyl)tetrahydro-2H-pyran-3-ol

: 1338566-13-4
ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

2: sodium hydrogencarbonate; methyl iodide / water; acetonitrile / 22 h / 20 °C

3: samarium diiodide / tetrahydrofuran; methanol / 0.5 h / 0 °C

4: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; samarium diiodide; sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ol202467z

Reference yield:

: 623-47-2
propynoic acid ethyl ester

: 1338566-13-4
ethyl ((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

2: sodium hydrogencarbonate; methyl iodide / water; acetonitrile / 22 h / 20 °C

3: samarium diiodide / tetrahydrofuran; methanol / 0.5 h / 0 °C

4: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; samarium diiodide; sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ol202467z