((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid

Base Information

• Chemical Name: ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid
• CAS No.: 97654-95-0
• Molecular Formula: C₂₀H₂₂O₆Se
• Molecular Weight: 437.351

Synonyms:((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid

Chemical Property of ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid

There total 8 articles about ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

((1S,2S,6R,8S,9S,12R)-2-Acetoxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.01,6]dodec-3-en-12-yl)-acetic acid methyl ester (97654-94-9) → ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.01,6]dodec-3-en-12-yl)-acetic acid (97654-95-0)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jo00221a019

Reference yield:

Phenylselenyl chloride (5707-04-0) → ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.01,6]dodec-3-en-12-yl)-acetic acid (97654-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / K₂CO₃ / CH₂Cl₂ / 4 h

2: 63 percent / 1 N aq. NaOH / methanol / 2 h / Ambient temperature

With sodium hydroxide; potassium carbonate; In methanol; dichloromethane;

DOI:10.1021/jo00221a019

Reference yield:

3,5-Hexadiensaeure-methylester (40338-61-2) → ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.01,6]dodec-3-en-12-yl)-acetic acid (97654-95-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / 24 h / 55 °C

2: TsOH / CH₂Cl₂ / 0.33 h / 0 °C

3: 99 percent / NaBH₄ / methanol / 0.5 h / -40 °C

4: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

5: 1 N aq. HCl / methanol / 1 h / Ambient temperature

6: 79 percent / K₂CO₃ / CH₂Cl₂ / 4 h

7: 63 percent / 1 N aq. NaOH / methanol / 2 h / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo00221a019

upstream raw materials:

((1S,2S,6R,8S,9S,12R)-2-Acetoxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid methyl ester

Phenylselenyl chloride

3,5-Hexadiensaeure-methylester

((1S,4aR,8aS)-8a-Hydroxymethyl-7-methoxy-5,8-dioxo-1,4,4a,5,8,8a-hexahydro-naphthalen-1-yl)-acetic acid methyl ester

Downstream raw materials:

C₂₀H₂₀O₅Se

C₂₀H₂₀O₃Se

C₂₀H₂₀O₄Se

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 97654-95-0 ((1S,2S,6R,8S,9S,12R)-2-Hydroxy-3-methoxy-5-oxo-8-phenylselanyl-10-oxa-tricyclo[7.2.1.0^1,6]dodec-3-en-12-yl)-acetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send