1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

Base Information

Chemical Name:1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine
CAS No.:1204331-61-2
Molecular Formula:C₂₆H₂₇F₃N₄O₄
Molecular Weight:516.52
Hs Code.:

Synonyms:1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

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Chemical Property of 1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

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Technology Process of 1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

There total 22 articles about 1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204331-51-0
N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-N'-(carbobenzyloxy)-guanidine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1204331-61-2
1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

Guidance literature:: N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-N'-(carbobenzyloxy)-guanidine; cyclopropanecarboxylic acid chloride; With triethylamine; In dichloromethane; at 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1204331-61-2
1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 °C

1.2: -75 - 0 °C

1.3: 0.17 h / Cooling

2.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

4.1: water; potassium carbonate / methanol / 2 h / 60 °C

4.2: pH ~ 4

5.1: hydrogen / palladium 10% on activated carbon / methanol / 3102.97 Torr

6.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

7.1: hydrogenchloride / 1,4-dioxane / 16 h / 50 °C

8.1: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium acetate; potassium carbonate; triethylamine; lithium hexamethyldisilazane; (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; 3.1: Suzuki Coupling;

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1204331-61-2
1-(N-carbobenzyloxy)-3-[4-(1-cyclopropanecarbonyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

3.1: water; potassium carbonate / methanol / 2 h / 60 °C

3.2: pH ~ 4

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3102.97 Torr

5.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

6.1: hydrogenchloride / 1,4-dioxane / 16 h / 50 °C

7.1: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium acetate; potassium carbonate; triethylamine; (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; 2.1: Suzuki Coupling;