(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

Base Information

Chemical Name:(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester
CAS No.:247107-73-9
Molecular Formula:C₂₆H₃₆I₂N₄O₅
Molecular Weight:738.405
Hs Code.:

(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

Synonyms:(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

There total 14 articles about (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247107-71-7
(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

: 247107-73-9
(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 4h;
DOI:10.1002/(SICI)1521-3773(19990816)38:16<2447::AID-ANIE2447>3.0.CO;2-O

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 247107-73-9
(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / DBU / CH₂Cl₂ / 16 h / 25 °C

2: 90 percent / H₂ / [(S,S)-Et-DuP-Rh]⁺TfO^- / methanol / 96 h / 3102.97 Torr

3: 96 percent / H₂ / Pd/C / methanol / 12 h / 25 °C / 760.05 Torr

4: 78 percent / EDC; HOAt / CH₂Cl₂ / 3 h / 20 °C

5: 89 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 0 °C

6: 307 mg / HOAt; EDC; iPr₂NEt / CH₂Cl₂ / 4 h / 0 °C

7: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; (+)-1,2-bis((2S,5S)-2,5-diethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; In tetrahydrofuran; methanol; dichloromethane; 1: Condensation / 2: stereoselective hydrogenation / 3: Hydrogenolysis / 4: Acylation / 5: Hydrolysis / 6: Acylation / 7: acidolysis;
DOI:10.1021/ja994285v

Reference yield:

: 234122-64-6
(S)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoate

: 247107-73-9
(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / Pd/C / methanol / 12 h / 25 °C / 760.05 Torr

2: 78 percent / EDC; HOAt / CH₂Cl₂ / 3 h / 20 °C

3: 89 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 0 °C

4: 307 mg / HOAt; EDC; iPr₂NEt / CH₂Cl₂ / 4 h / 0 °C

5: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1: Hydrogenolysis / 2: Acylation / 3: Hydrolysis / 4: Acylation / 5: acidolysis;
DOI:10.1021/ja994285v