(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Base Information

Chemical Name:(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester
CAS No.:186425-37-6
Molecular Formula:C₅₂H₈₄O₇Si₂
Molecular Weight:877.406
Hs Code.:

(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Synonyms:(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Suppliers and Price of (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

There total 24 articles about (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 186425-19-4
(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-hydroxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

: 74-88-4
methyl iodide

: 186425-37-6
(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 0 ℃; for 6h;
DOI:10.1016/S0040-4039(96)02132-6

Reference yield:

: 994-30-9
triethylsilyl chloride

: 186425-37-6
(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: imidazole, DMAP / CH₂Cl₂ / 18 h

2: 88 percent / PPTS / propan-2-ol / 8 h

3: 96 percent / MnO₂ / CH₂Cl₂ / 3 h

4: 87 percent / LiHMDS, ZnCl₂ / tetrahydrofuran / 0.75 h / -78 - -50 °C

5: pyridine, DMAP / CH₂Cl₂ / 4 h / -78 - 0 °C

6: DBU / benzene / 2 h / 10 °C

7: 65 percent / Zn(BH₄)2 / diethyl ether / 48 h / -78 - -25 °C

8: 80 percent / KHMDS / tetrahydrofuran / 6 h / -78 - 0 °C

With pyridine; 1H-imidazole; dmap; manganese(IV) oxide; zinc(II) tetrahydroborate; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; benzene;
DOI:10.1016/S0040-4039(96)02132-6

Reference yield:

: 87717-21-3
ethyl α-(diisopropoxyphosphinyl)propionate

: 186425-37-6
(2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 81 percent / tBuOK / tetrahydrofuran / 15 h / -78 - 20 °C

2: 78 percent / TBAF / tetrahydrofuran / 15 h

3: imidazole, DMAP / CH₂Cl₂ / 18 h

4: 88 percent / PPTS / propan-2-ol / 8 h

5: 96 percent / MnO₂ / CH₂Cl₂ / 3 h

6: 87 percent / LiHMDS, ZnCl₂ / tetrahydrofuran / 0.75 h / -78 - -50 °C

7: pyridine, DMAP / CH₂Cl₂ / 4 h / -78 - 0 °C

8: DBU / benzene / 2 h / 10 °C

9: 65 percent / Zn(BH₄)2 / diethyl ether / 48 h / -78 - -25 °C

10: 80 percent / KHMDS / tetrahydrofuran / 6 h / -78 - 0 °C

With pyridine; 1H-imidazole; dmap; manganese(IV) oxide; zinc(II) tetrahydroborate; potassium tert-butylate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; benzene;
DOI:10.1016/S0040-4039(96)02132-6