1-BROMO-2,4-DIFLUORO-3-METHYLBENZENE

Base Information

• Chemical Name: 1-BROMO-2,4-DIFLUORO-3-METHYLBENZENE
• CAS No.: 221220-97-9
• Molecular Formula: C7H5 Br F2
• Molecular Weight: 207.018
• Hs Code.: 2903999090
• Mol file: 221220-97-9.mol

Synonyms:1-Bromo-2,4-difluoro-3-methylbenzene;2,4-Difluoro-3-methyl-1-bromobenzene; 3-Bromo-2,6-difluorotoluene

Chemical Property of 1-BROMO-2,4-DIFLUORO-3-METHYLBENZENE

Chemical Property:

• Vapor Pressure: 1.62mmHg at 25°C
• Refractive Index: 1.510
• Boiling Point: 174℃
• Flash Point: 59℃
• PSA: 0.00000
• Density: 1.588
• LogP: 3.03570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-2,4-difluoro-3-methylbenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-2,4-DIFLUORO-3-METHYLBENZENE

There total 3 articles about 1-BROMO-2,4-DIFLUORO-3-METHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluorotoluene (443-84-5) → 1-bromo-2,4-difluoro-3-methylbenzene (221220-97-9)

Guidance literature:

With bromine; iron; at 20 - 30 ℃; for 12h;

Reference yield:

n-butyllithium (109-72-8,29786-93-4) + 2,4-difluorobromobenzene (348-57-2) + methyl iodide (74-88-4) → 1-bromo-2,4-difluoro-3-methylbenzene (221220-97-9)

Guidance literature:

With diisopropylamine; In tetrahydrofuran;

Reference yield:

n-butyllithium (109-72-8,29786-93-4) + 2,4-difluorobromobenzene (348-57-2) + diisopropylamine (108-18-9) + methyl iodide (74-88-4) → 1-bromo-2,4-difluoro-3-methylbenzene (221220-97-9)

Guidance literature:

diisopropylamine; In tetrahydrofuran; Cooling with acetone-dry ice;

n-butyllithium; In hexane; for 0.25h;

2,4-difluorobromobenzene; methyl iodide; more than 3 stages;

upstream raw materials:

2,6-difluorotoluene

n-butyllithium

2,4-difluorobromobenzene

methyl iodide

Downstream raw materials:

2,4-difluoro-3-methylbenzonitrile

C₁₆H₁₀F₂O

2,4-difluoro-3-methylbenzoic acid

2,4-difluoro-3-methylbenzaldehyde

Refernces

• 1、 -. "Process for making certain benzoic acid compounds". Page column 11. . Retrieved 2010/01/30.