4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile

Base Information

• Chemical Name: 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile
• CAS No.: 171815-21-7
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.213
• Mol file: 171815-21-7.mol

Synonyms:4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile

Chemical Property of 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile

There total 2 articles about 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

sodium cyanide (143-33-9,25596-52-5) + 4,5-dihydro-3-nitro-4-(phenylmethoxy)isoxazole (171815-20-6) → 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile (171815-21-7)

Guidance literature:

In dimethyl sulfoxide; for 0.416667h;

DOI:10.1021/jo00125a015

Reference yield:

<<1-(chloromethyl)-2-nitroethoxy>methyl>benzene (171815-19-3) → 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile (171815-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / NaNO₂, n-propyl nitrite / dimethylsulfoxide / 4 h / 50 - 52 °C

2: 84 percent / dimethylsulfoxide / 0.42 h

With n-propyl nitrite; sodium nitrite; In dimethyl sulfoxide;

DOI:10.1021/jo00125a015

Reference yield: 88.0%

sodium ethanolate (141-52-6) + 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarbonitrile (171815-21-7) → ethyl 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarboxylate (171815-24-0)

Guidance literature:

In ethanol;

DOI:10.1021/jo00125a015

upstream raw materials:

sodium cyanide

4,5-dihydro-3-nitro-4-(phenylmethoxy)isoxazole

<<1-(chloromethyl)-2-nitroethoxy>methyl>benzene

Downstream raw materials:

ethyl 4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarboxylate

4,5-dihydro-4-(phenylmethoxy)-3-isoxazolecarboxaldehyde

4,5-dihydro-3-(1,3-dithiolan-2-yl)-4-(phenylmethoxy)isoxazole

(R*,R*)-γ-amino-β-(phenylmethoxy)-1,3-dithiolane-2-propanol