1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

Base Information

Chemical Name:1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine
CAS No.:925216-62-2
Molecular Formula:C₂₃H₃₁N₇O₃
Molecular Weight:453.544
Hs Code.:

Synonyms:1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

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Chemical Property of 1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

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Technology Process of 1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

There total 7 articles about 1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 70-25-7
N-Methyl-N'-nitro-N-nitrosoguanidine

: 75821-80-6
1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine

: 925216-62-2
1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

Guidance literature:: In ethanol; water; for 6h; Heating / reflux;

Reference yield:

: 5099-39-8
N⁽¹⁾-(2-(diethylamino)ethyl)-4-nitrobenzene-1,2-diamine

: 925216-62-2
1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 18 h / 35 °C / Inert atmosphere

2: phosphorus trichloride / chloroform / 4 h / Reflux; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C

4: ethanol / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; phosphorus trichloride; In ethanol; dichloromethane; chloroform;
DOI:10.1021/ml200268w

Reference yield:

: 56223-91-7
N’-(2,4-dinitrophenyl)-N,N-diethylethane-1,2-diamine

: 925216-62-2
1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium sulfide / ethanol; water / 2.5 h / 65 - 70 °C / Inert atmosphere

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 18 h / 35 °C / Inert atmosphere

3: phosphorus trichloride / chloroform / 4 h / Reflux; Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C

5: ethanol / Inert atmosphere; Reflux

With ammonium sulfide; palladium 10% on activated carbon; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; phosphorus trichloride; In ethanol; dichloromethane; chloroform; water; 1: Zinin reduction;
DOI:10.1021/ml200268w