4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

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Chemical Name:4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid
CAS No.:452343-18-9
Molecular Formula:C₃₉H₂₈N₄O₂
Molecular Weight:584.677
Hs Code.:

Synonyms:4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

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Chemical Property of 4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

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Technology Process of 4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

There total 8 articles about 4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446880-83-7
2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine

: 14047-29-1
4-carboxyphenylboronic acid

: 452343-18-9
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

Guidance literature:: 2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine; 4-carboxyphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾;

With sodium hydroxide;

Reference yield:

: 452343-16-7
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester

: 452343-18-9
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; Heating;
DOI:10.1021/jm0509905

Reference yield:

: 446852-65-9
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one

: 452343-18-9
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / dimethylformamide / 1.3 h / 20 °C

2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C

3: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

4: 83.6 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating

5: aq. NaOH / ethanol / Heating

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide; acetone; toluene; 4: Suzuki coupling;
DOI:10.1021/jm0509905