Methyl 4-(4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl)benzoate

Base Information

Chemical Name:Methyl 4-(4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl)benzoate
CAS No.:452343-16-7
Molecular Formula:C₄₀H₃₀N₄O₂
Molecular Weight:598.704
Hs Code.:
Mol file:452343-16-7.mol

Synonyms:4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester

Suppliers and Price of Methyl 4-(4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Methyl 4-(4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl)benzoate

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl 4-(4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl)benzoate

There total 6 articles about Methyl 4-(4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

: 446880-83-7
2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 452343-16-7
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 2h; Heating;
DOI:10.1021/jm0509905

Reference yield:

: 446852-65-9
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one

: 452343-16-7
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / dimethylformamide / 1.3 h / 20 °C

2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C

3: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

4: 83.6 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide; acetone; toluene; 4: Suzuki coupling;
DOI:10.1021/jm0509905

Reference yield:

: 446880-81-5
2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine

: 452343-16-7
4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

2: 83.6 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; acetone; toluene; 2: Suzuki coupling;
DOI:10.1021/jm0509905