4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

Base Information

Chemical Name:4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide
CAS No.:1202920-35-1
Molecular Formula:C₁₄H₁₄ClN₃O₅
Molecular Weight:339.735
Hs Code.:

Synonyms:4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

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Chemical Property of 4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

Chemical Property:

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Technology Process of 4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

There total 4 articles about 4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202920-38-4
4-acetylamino-5-(2,4-bis-benzyloxy-5-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide

: 1202920-35-1
4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: 4-acetylamino-5-(2,4-bis-benzyloxy-5-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide; With boron trichloride; In dichloromethane; at 0 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 747413-05-4
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide

: 1202920-35-1
4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

2: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

3: triethylamine / dichloromethane / 5 h / Inert atmosphere

4: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

With water; nitric acid; acetic anhydride; boron trichloride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201155e

Reference yield:

: 1202920-36-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

: 1202920-35-1
4-acetylamino-5-(5-chloro-2,4-dihydroxyphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

2: triethylamine / dichloromethane / 5 h / Inert atmosphere

3: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

With water; boron trichloride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201155e